Yurtdışı stajı

Değerli Arkadaşlarım,
Daha önce konuşulduğu gibi her yıl yurtdışına 2 öğrencimizin 1er aylık gidişine Sanofi-Aventis firması destek olacak.
Bu taahhüt hala geçerli. Ancak S-A, öğrencilerin kendilerinin bir merkezle yazışıp, anlaşmalarını istiyor. Oradaki masraflarını ve yol paralarını karşılayacağını ifade ediyor.
İki öğrenci AEP öğrencileri arasından olacak. Öğrencilerimiz yazışma ve kabullerini sağladıktan sonra seçim yapılmasının uygun olmayacağını düşündük. Hayal kırıklıkları olacaktır. Bu nedenle ilerlemeler sağlanmadan kendi aranızdan iki arkadaşınızı seçebilir misiniz? Sizin 2 kişiyi belirlemenizi tercih ederiz. Eğer bu mümkün olmazsa istekli arkadaşlarımız öğrenci işlerinden Nevin Hanıma veya ulusakarca@gmail.com adresine bilgi verebilirler.
8 Mayıs günü öğleden sonraki 2 saat hep beraber olacağız. Gelişmeleri sizden dinleyeceğiz. Formal bir sunum hazırlanmasına gerek yoktur.

AEP İngilizce Makale

Arkadaşlar alttaki makalenin tamamını 25 Nisana kadar hepimizin çevirip o günkü derse basılı olarak getirmemiz gerekiyormuş. 


BUNDAN NOT ALACAKMIŞIZ


O gün yanımızda getirip Nevbahar hocamıza teslim etmemiz gerekiyormuş.
Bu ödevin bir kopyası portfolyolarımıza konacakmış.


Yarınki BYS'de hepimize başarılar dilerim :)

Frequent Chocolate Consumption Linked to Lower BMI

March 26, 2012 — A recent study showed that frequent chocolate consumption was associated with lower body mass index (BMI), even when adjusting for calorie intake, saturated fat intake, and mood.

Beatrice A. Golomb, MD, PhD, associate professor of medicine at the University of California, San Diego, and colleagues described their findings in a research letter published in the March 26 issue of the Archives of Internal Medicine.

The authors used data from 1018 patients already being screened for inclusion in a widely sampling clinical study evaluating noncardiac effects of statin medications. Of the 1018 participants, 1017 answered the question, "How many times a week do you consume chocolate?" BMI was calculated for 972 participants (95.6%); and 975 (95.8%) answered the validated Fred Hutchinson Food Frequency Questionnaire.

The investigators performed analyses with and without adjustment for calorie intake, saturated fat (satfat) intake, and mood. Fruit and vegetable intake was not associated with chocolate consumption (β, 0.004; P = .55), but satfat intake was significantly related to both chocolate consumption (β, 0.035; P < .001) and higher BMI.

The amount of chocolate consumed was examined, in addition to the frequency of chocolate consumption. Activity (number of times in a 7-day period the participant engaged in vigorous activity for at least 20 minutes) and mood (Center for Epidemiological Studies Depression scale [CES-D]) were also examined.

The relationship between chocolate consumption frequency and BMI was calculated in unadjusted models, in models adjusted for age and sex, and in models adjusted for activity, satfats, and mood.

Study participants consumed chocolate a mean 2.0 (SD, 2.5) times per week and exercised 3.6 (SD, 3.0) times per week. Frequency of chocolate consumption was associated with greater intake of calories and satfats and higher CES-D scores (P < .001 for each of these 3 associations); these all related positively to BMI. Chocolate consumption frequency was not associated with greater activity (P = .41), but it was associated with lower BMI (unadjusted P = .01). This association remained with and without adjustment for age and sex, as well as for calories, satfats, and depression.

Although chocolate consumption frequency was associated with lower BMI, the amount of chocolate consumed was not (eg, per medium chocolate serving or 1 oz [28 g], β, 0.00057 and P = .97, in an age- and sex-adjusted model).

"The connection of higher chocolate consumption frequency to lower BMI is opposite to associations presumed based on calories alone, but concordant with a growing body of literature suggesting that the character — as well as the quantity — of calories has an impact on [metabolic syndrome (MetS)] factors," write the authors.

They further explain that as chocolate products are frequently high in sugar and fat, they are often assumed to contribute to an increased BMI. The authors note that this may still be true in some cases.

"[O]ur findings — that more frequent chocolate intake is linked to lower BMI — are intriguing," write the authors. "They accord with other findings suggesting that diet composition, as well as calorie number, may influence BMI. They comport with reported benefits of chocolate to other elements of MetS," the authors write, noting that a randomized trial studying the metabolic benefits of chocolate in humans may be warranted.

This study was funded by a grant from the National Heart, Lung and Blood Institute, National Institutes of Health, and was supported by the University of California, San Diego, General Clinical Research Center. The authors have disclosed no relevant financial relationships.

Discovery Hints at Why Cardiac Death Risk Is Highest in Early Morning

Discovery Hints at Why Cardiac Death Risk Is Highest in Early Morning

Febraury 24, 2012 (Cleveland, Ohio) — Researchers have identified a molecule that links circadian rhythms to ventricular arrhythmias in an animal model, with the results providing a greater understanding as to why certain cardiovascular events, specifically those with an underlying arrhythmogenic etiology, occur in the early-morning hours [1].

In the study, published online February 22, 2012 in Nature, the researchers, led by Dr Darwin Jeyaraj (Case Western Reserve University School of Medicine, Cleveland, OH), report that cardiac ion-channel expression and QT-interval duration exhibit an endogenous circadian rhythm that is under the control of the transcription factor Krüppel-like factor 15 (Klf15).

"The study showed that this factor, Klf15, regulates the electrical activity of the heart, and second, we linked it to the endogenous 24-hour rhythms, the so-called daily biological clock," senior investigator Dr Mukesh Jain (University Hospitals Case Medical Center and Case Western Reserve University) told heartwire . "If there is a singular line that encapsulates the work, it's that Klf15 is the first link between the biological clock and arrhythmogenesis."

Maybe It's Best to Stay in Bed?

In an interview, Jain explained that the incidence of sudden cardiac death, including both the hereditary and acquired forms of heart disease, exhibits a diurnal variation, with the occurrence of sudden death increasing within a few hours of waking in the morning and a second peak observed in the evening. MI, various arrhythmias, and even ruptures of the aortic aneurysm also tend to occur in the morning or in the early waking hours. Other biological parameters, including blood pressure, heart rate, vascular tone, and QT interval, also exhibit diurnal variation.

Calling Klf15 a "fascinating molecule," one that is conserved across species and is expressed in muscle tissue, Jain noted that his laboratory first identified the transcription factor about 10 years ago and published studies showing that animals deficient in Klf15 develop heart failure and aortic aneurysms. In the present study, the researchers wanted to determine whether Klf15 also regulated electrical activity and, given that heart failure and aortic aneurysms exhibited this diurnal pattern, also sought to determine whether Klf15 linked electrical regulation with the body's biological clock.

"There is something provocative about why these events should happen at certain times of the day, and it has been talked about, conjuring up all kinds of theories as to why this might happen," said Jain.

In their study, the researchers identified a specific ion channel under the control of Klf15. They showed the transcription factor controls the expression of voltage-gated potassium (Kv) channel-interacting protein 2 (KChIP2), a protein that is needed to create the transient outward potassium current. In linking Klf15 to the circadian rhythm, they examined 5kb of the promoter region of Klf15 and identified binding sites for CLOCK and BMAL1, two transcription factors that are involved in the circadian clock. In in vivo loss- and gain-of-function mouse models, they found that deficiencies or excesses of Klf15 can cause the loss of rhythmic QT variations, abnormal repolarization, and ventricular arrhythmias.

Regarding the next steps, Jain said his group would like to determine whether Klf15 can regulate other processes and whether it might also be responsible for the occurrence of heart failure and aneurysm during certain times of the day. Down the road, the group would also like to determine whether mutations in Klf15 might be observed in patients at high risk for sudden death or even in healthy populations, as this might help illuminate some of the seemingly unexplainable cases of sudden cardiac death.

"There are two patient populations, broadly speaking, that are susceptible to sudden death," Jain told heartwire . "One is those with known heart disease, but I also really want to highlight that there is a whole swath of patients, some of whom are quite young and in the prime of their life, for whom we don't have an explanation. We would like to look at Klf15 mutations or polymorphisms not only in populations like heart-disease patients; I think we have to look at it quite broadly."

Klf15 also offers has some diagnostic potential, and that would include developing chemical compounds to manipulate Klf15 to reduce the risk of sudden cardiac death.

AEP İngilizce Dersi için Makale Linki...

Sevgili Öğrencilerimiz,

19 Mart 2012 haftasında AEP İngilizce dersi için üzerinde çalışacağınız Why is Cardiac Death Risk Highest in Early Morning? başlıklı makaleye ulaşmak için TIKLAYINIZ.

Sevgiler, iyi haftalar...

Araştırma Alanları ve Danışmanlar

Değerli Öğrencilerimiz,
Aşağıda seçtiğiniz araştırma alanları ve danışman öğretim üyeleri bulunmaktadır. Bu seçimlerde değişiklik talebiniz olursa lütfen komisyona bildiriniz. Alanı kesinleşmemiş olan iki arkadaşımız 6 Mart öğleden sonra görüşmelerini tamamlayabilir. Danışmanlar için hazırlanmış olan kılavuz sizi de ilgilendirmektedir. Bu kılavuza ulaşmak için tıklayınız.
6 Mart öğleden sonra danışman öğretim üyeleriniz ile görüşmek üzere ilgili bilim dallarına gidiniz. Sonraki ilerlemeleri öğretim üyeleriniz ile görüşeceksiniz. İlk gün öğretim üyelerinden fazla birşey beklemeyiniz 

Adı	Soyadı	Bilim Dalı	Öğretim Üyesi
Ahmet	ÇETİNKAYA	Tıbbi Biyoloji	Cumhur Gündüz
Ahmet Mürsel	ULAŞAN	Tıbbi Biyoloji	Zuhal Eroğlu
Aybike	ERDEM	Tıbbi Biyoloji	Buket Kosova
Aysu	YÖNETİCİ	Tıbbi Genetik	Ferda Özkınay
Bengisu	KESKİN	Göğüs Hastalıkları	Özen Başoğlu
Bilçağ	AKGÜN	Tıbbi Genetik	Özgür Çoğulu
Burak	YILMAZ
Çağatay	ERMİŞ	Tıbbi Biyoloji	Cumhur Gündüz
Didem	ŞENSES	Farmakoloji	Aytül Önal
Ecem	AY	Mikrobiyoloji	Selda Erensoy
Ezgi	KARAGÖZ	Yenidoğan	Nilgün Kültürsay, Mehmet Yalaz
Göksel	TANIGÖR	Yenidoğan	Nilgün Kültürsay, Mehmet Yalaz
Gurur	GARİP	Çocuk nefrolojisi	Sevgi Mir
Gülşah	KOÇAK	Parazitoloji	Yüksel Gürüz
İlkay	KALKANLI	Nefroloji	Soner Duman
Kıvanç	GÖMEÇ	Mikrobiyoloji	Selda Erensoy
Mehmet Sadık	LAÇİN	Gastroenteroloji-Patoloji	Funda Yılmaz-Ulus Akarca
Meriç	YALÇINLI	Tıbbi Genetik	Hüseyin Onay
Onur	FURUNDAOTURAN	Tıbbi Genetik	Haluk Akın
Onur	KÜÇÜKKAYA	Patoloji	Mine Hekimgil
Ozan Utku	ÖZTÜRK	Gastroenteroloji	Nevin Oruç
Sedat	BAKIR	Hematoloji-Biyokimya	Ayhan Dönmez-Ceyda Kabaroğlu
Sinem	ÇİLİNGİR

AEP İngilizce Dersi

Değerli Öğrencilerimiz,
AEP İngilizce derslerini üstlendiği için ve pozitif yaklaşımı için Sayın Prof Dr Nevbahar Turgan'a çok teşekkür ederiz.
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